Obeticholic acid amagwiritsidwa ntchito yekha kapena osakaniza mankhwala a chiwindi matenda (primary biliary cholangitis-PBC).
Dzina lazogulitsa | Obeticholic Acid |
Dzina la Chemical | 6-Ethylchenodeoxycholic acid |
Dzina Lina | 3A, 7A -DIHYDROXY-6A -ETHYL-5B-CHOLAN-24-OIC ACID;Obeticholic acid 6-ECDCA;6alpha-Ethyl-chenodeoxycholic acid;6-Ecdca;6-Ethylchenodeoxycholic acid;6alph47 Acid7,6; - ECDCA) |
Nambala ya CAS | 459789-99-2 |
Molecular Formula | C26H44O4 |
Kulemera kwa Formula | 420.63 |
Maonekedwe | White ufa |
Kuyesa | 99.0% mphindi |
Kuchulukana | 1.091 g/cm3 |
Melting Point | 108-110 ° C |
Boiling Point | 562.9±25.0 °C |
Phukusi | 20kg / thumba / ng'oma, 25kg / thumba / ng'oma, kapena momwe mungafunire |
Kusungirako | Sungani chidebecho chotsekedwa mwamphamvu pamalo owuma ndi ozizira.Osawonetsa kuwala kwa dzuwa. |
COA & MSDS | Likupezeka |
Obeticholic acid ndi dihydroxy-5beta-cholanic acid yomwe ndi chenodeoxycholic acid yomwe imanyamula zowonjezera za ethyl pa 6alpha-position.Semisynthetic bile acid yomwe imakhala ngati farnesoid X receptor agonist ndipo imagwiritsidwa ntchito pochiza cholangitis chachikulu cha biliary.Ili ndi gawo ngati farnesoid X receptor agonist ndi hepatoprotective agent.Ndi dihydroxy-5beta-cholanic acid, 3alpha-hydroxy steroid ndi 7alpha-hydroxy steroid.Amachokera ku chenodeoxycholic acid.
Obeticholic acid (OCA) ndi bile acid yosinthidwa mwachilengedwe komanso agonist wamphamvu wa farnesoid X nuclear receptor (FXR) yomwe imagwiritsidwa ntchito pochiza matenda a chiwindi kuphatikizapo primary biliary cholangitis.
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Nthawi yotsogolera
≤100kg: mkati mwa masiku atatu ogwira ntchito mutalandira malipiro.
>100kg: sabata imodzi
Chitsanzo
Likupezeka.
Phukusi
20kg/thumba/ng'oma, 25kg/thumba/ng'oma
kapena momwe mungafunire.
Kusungirako
Sungani chidebecho chotsekedwa mwamphamvu pamalo owuma ndi ozizira.
Osawonetsa kuwala kwa dzuwa.