Cetylpyridinium chloride ngati Chithandizo cha COVID-19

Kuyesaku kunawonetsa kuchuluka kwa mankhwala ophera tizilombo toyambitsa matenda a quaternary ammonium monga chithandizo cha ma virus ambiri, kuphatikiza ma coronaviruses: izi zimachitika poletsa zokutira zoteteza za lipid zomwe zimakutira ma virus ngati SARS-CoV-2 amadalira.Ma quaternary ammonium compounds amalimbikitsidwa kwambiri kuti aphe ma virus ndipo pali zinthu zopitilira 350 pa EPA's List N: Mankhwala opha tizilombo toyambitsa matenda omwe amagwiritsidwa ntchito polimbana ndi SARS-CoV-2 (Supplementary Material. mankhwala omwe ali pamndandanda wa EPA adanenedwa ndipo> 140 amatha kuletsa kachilomboka pakangopita mphindi zochepa (18).
Izi zidatitsogolera pakusaka kokulirapo kwa mankhwala a quaternary ammonium okhala ndi zochita zolimbana ndi ma coronaviruses komanso kuzindikira mankhwala omwe adayesedwa kale kuchipatala ndipo atha kugwiritsidwa ntchito ngati chithandizo cha COVID-19.Mmodzi mwa mankhwala ophera tizilombo omwe awonetsedwa kuti amawononga ma virus (Supplementary Material) ndipo amagwiritsidwa ntchito kwambiri pazinthu zosamalira anthu ndi cetylpyridinium chloride.Gululi limapezeka kwambiri m'malo otsuka pakamwa ndipo limalembedwa ndi FDA monga Generally Regarded As Safe (GRAS) kotero kuti likugwiritsidwanso ntchito ngati antimicrobial wothandizira nyama ndi nkhuku (mpaka 1%).Cetylpyridinium chloride yakhala ikugwiritsidwa ntchito m'mayesero angapo azachipatala, kuphatikiza ngati chithandizo chothana ndi matenda opumira omwe amatsimikizira kugwiritsidwa ntchito kwake ngati antiviral.Cetylpyridinium mwina imathandizira kuti ma virus ayambe kugwira ntchito powononga capsid komanso kudzera mu zochita zake za lysosomotropic, zomwe, monga tafotokozera pamwambapa, ndizofala pamagulu a quaternary ammonium.Izi zimadzutsa funso ngati mankhwala ena omwe amadziwika kuti ali ndi antivayirasi yolimbana ndi SARS-CoV-2 mu vitro amachita chimodzimodzi, kutanthauza kuti amatha kuwononga kachilombo ka capsid komanso kudziunjikira mu lysosome kapena endosomes ndikuletsa kulowa kwa ma virus.Kafukufuku wowonjezera omwe adasindikizidwa awonetsa kuti izi zitha kuchepetsedwa pogwiritsa ntchito Cathepsin-L inhibitors.

 Cetylpyridinium chloride (CPC)

Mitundu ya Quaternary ammonium yokhala ndi zochitika zodziwika za coronavirus